Exemestane is the active substance of the brand Aromasin – the oldest and most popular brand for this chemical, yet, it can be found as numerous other brands too. This is an orally active drug that is FDA approved and medically used for treating breast cancer in women, therefore is often seen as an anti cancer medication.

Nonetheless, is in the class of drugs known as Aromatase Inhibitors (AIs) like Arimidex (Anastrozole) and Femara (Letrozole).

Exemestane (Aromasin), however, is different from the other 2 famous AIs because it is a suicidal AI, unlike the other 2 AIs mentioned. Being a “suicidal” AI, as soon as it binds to the aromatase enzyme – it permanently disables the aromatization.

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This means that Exemestane is not going to allow estrogen rebounding and is not going to temporarily stop estrogen receptors from aromatization like Anastrozole or Letrozole would, allowing for estrogen rebound. That’s why some steroid users may experience high estrogen related issues with other AIs after they stop the administration, but they can’t experience them with Exemestane – Aromasin.

• Exemestane is very effective at reducing estrogen because it lowers estrogen levels up to about 85%.

Exemestane Bodybuilding

Despite the fact that Exemestane (Aromasin) is mostly considered an anti cancer drug in medical settings and is approved as a cancer treatment compound among women, this drug is very popular in bodybuilding. That’s because it is effective at lowering estrogen levels.

Those who run anabolic steroids are having high chances to get a spike in estrogen levels.

• Not all steroids convert into estrogen, DHT derived ones like Stanozolol, Oxandrolone, Methenolone etc. – don’t convert into estrogen.

But most of the bulking compounds including Testosterone that is generally recommended to be added in all cycles – they do convert into estrogen in the body.

• Those steroids that are converted into estrogen are: Dianabol, Nandrolone, Boldenone and as mentioned – Testosterone, including many others too.

In case you run such steroids without controlling estrogen, there’s a high risk you would run high estrogen levels which results in different side effects like for example blood pressure, water retention, heart issues and one of the worst (as considered by bodybuilders): gynecomastia.

High estrogen levels would lead to many different nasty symptoms and side effects, even including interfering with normal testosterone levels.

Exemestane Side Effects

We mentioned why bodybuilders should run Exemestane (Aromasin) but you need to know how to run it properly in order to stay away from the possible side effects.

The gold rule – never use too much.

If you’re going to use Exemestane too much, that’s going to eliminate too much estrogen and without enough estrogen levels, that’s going to offer many nasty symptoms too such as: dry joints, negative effects on libido, low energy, insomnia, irritability, inability to gain muscles and strength including many others.

Exemestane in bodybuilding is used so it would CONTROL the estrogen. You need to make sure to use proper doses so the estrogen levels are within normal range. Not too much and or too little.

If the estrogen levels are maintained in normal range – you are unlikely to get Exemestane side effects.

Exemestane Dosage

The proper dosage of Exemestane for estrogen control on-cycle greatly depends on the amount of steroids, type of steroids and dosage of steroids used. It also depends on how prone you are to get estrogen related side effects, how you respond to this medication itself including a number of other factors.

That’s why Exemestane dosages are highly individual, depending on different things.

• Generally, most bodybuilders start using Aromasin (Exemestane) in doses around 12.5 mg every other day. Because it is orally active, is easy to administer and because it has a half life of 25-27 hours, you can use it every other day or maximum once per day.
• In case that’s not enough to deal with estrogen related side effects (or, as is recommended, you go for a blood work and the estrogen levels are still high), you may go for 25 mg every other day or 12.5 mg per day. Maximum a bodybuilder (who runs serious cycles) might need 25 mg per day of Aromasin– Exemestane.

Keep in mind that in case you get too low estrogen symptoms (for example joint issues) or blood levels – the dosages should be lowered.

In case you get too high estrogen symptoms (sensitive nipples or water retention) or blood levels – increase the dosage.

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